Yes, calling s[0:-1] is exactly the same as calling s[:-1].
Using a negative number as an index in python returns the nth element from the right-hand side of the list (as opposed to the usual left-hand side).
so if you have a list as so:
myList = ['a', 'b', 'c', 'd', 'e']
print myList[-1] # prints 'e'
the print statement will print "e".
Once you understand that (which you may already, it's not entirely clear if that's one of the things you're confused about or not) we can start talking about slicing.
I'm going to assume you understand the basics of a slice along the lines of myList[2, :4] (which will return ['c', 'd']) and jump straight into the slicing notation where one side is left blank.
As you suspected in your post, myList[:index] is exactly the same as myList[0:index].
This is also works the other way around, by the way... myList[index:] is the same as myList[index:len(myList)] and will return a list of all the elements from the list starting at index and going till the end (e.g. print myList[2:] will print ['c', 'd', 'e']).
As a third note, you can even do print myList[:] where no index is indicated, which will basically return a copy of the entire list (equivalent to myList[0:len(myList)], returns ['a', 'b', 'c', 'd', 'e']). This might be useful if you think myList is going to change at some point but you want to keep a copy of it in its current state.
If you're not already doing it I find just messing around in a Python interpreter a whole bunch a big help towards understanding these things. I recommend IPython.
