Sapphire Ventures

As cyber threats grow more sophisticated, from ransomware and data breaches to risks emerging from new AI tools, organizations need innovative defenses to stay protected. That’s why we’re proud to see three of our portfolio companies recognized on Fortune’s Cyber 60 list in the growth stage category. Congratulations to GitGuardian, Huntress, and Cyera! 👏 Full list here: https://lnkd.in/gdAHwEi6

Last week, I had the pleasure of hosting Sapphire Ventures’ Enterprise Technology Executives Dinner in San Francisco. Rami Branitzky and I brought together an incredible group of CIOs, CTOs, and technology leaders from companies like SAP, Mercedes-Benz USA, ADT, J.P. Morgan, Freshfields, and C3 AI, among others. Our goal was simple: to create space for peer-to-peer conversation about where AI is actually driving value in the enterprise. The discussion centered around the rise of agentic AI systems, moving from copilots to autonomous agents capable of taking contextual action across complex enterprise environments. A few of the recurring themes: ➡️ The agentic shift |  Enterprises are starting to operationalize AI agents for real business outcomes, from IT automation and risk management to customer engagement and logistics optimization. ➡️ Architecture and orchestration | Teams are exploring how to balance centralized vs. domain-specific agent architectures, and how to integrate agents safely into production workflows. ➡️ Governance and security | As AI gains system-level access, fine-grained controls, auditability, and identity management are becoming top-of-mind for CIOs and CISOs. ➡️ From pilot to production | Many leaders shared lessons on moving beyond experimentation, emphasizing culture, data readiness, and change management as key enablers. ➡️ Human + machine collaboration | The future of enterprise AI isn’t fully autonomous; it’s about building systems where humans and AI can reason, decide, and execute together. Huge thank you to everyone who joined and to our Sapphire portfolio leaders from Glean and Hightouch for sharing their firsthand perspectives on deploying AI at scale. If you’re a CIO, CTO, or tech executive interested in connecting with our growing enterprise community or joining for a future dinner, feel free to reach out! Gilles Drieu Henrik Ohlsson Beti Cung Beth George Neboysa Omcikus Eric Tan Kashish Gupta Sam Yen Timo Stelzer Kiran Kaza Charles Nwatu Ajesh Purushothaman

AI is part of nearly every startup technology out there these days. For CIOs, evaluating which is legitimate and useful is crucial.  At our 4th Annual Hypergrowth Engineering Summit earlier this year, Mike Hamilton, CIO of Cloudflare shared what he values most when assessing new technologies: 🔹Continuous adoption as the real measure of success—watching whether people keep using an AI tool over time or turn it off after a few weeks is the real insight. 🔹 Trust and partnership with early-stage innovators, with transparency and a willingness to share what they’re learning on the bleeding edge. 🔹 Above all, substance over hype, AI that truly learns and acts autonomously, not another chatbot with a new label. Watch more of Mike’s hot takes below. ⬇ And explore top highlights from our Engineering Summit here: https://lnkd.in/gXF3-QPN

We’re proud to share that Sapphire Ventures has once again been named to Inc. Magazine’s 2025 Founder-Friendly Investors list–our 5th year in a row!  🎉 At Sapphire Ventures, our goal has always been to be true partners to the founders and CEOs we back. This recognition underscores the value of those partnerships and the importance of entrepreneur-investor fit. 🤝 A big thank-you to our portfolio founders and CEOs for trusting us to be part of your journey. Check out the full 2025 Founder-Friendly Investors list: https://lnkd.in/eWKqShcN

Jai Das is headed to The Wall Street Journal Tech Live 2025 in a couple weeks, where he’ll join top investors and innovators to discuss the next big bets in tech and venture. In a “Masterclass” panel moderated by Ben Ashwell (Chair and Editor, CFO and Technology Councils, WSJ Leadership Institute), Jai will join Enrique Salem, Bain Capital Ventures (BCV), for a discussion on the outlook for VC in 2026, spotting the next billion-dollar ideas, and reflecting on the wins from this year. If you’re at WSJ TechLive, don’t miss this session: 📅 November 5 | 3–4 PM PT 📍 Napa, CA

Congratulations to Anrok on the $55M Series C! 👏 Michelle Valentine and her team have built a platform that’s redefining global sales tax compliance for the modern economy by helping companies automate complex processes and stay compliant as they scale. With over 40% of the Forbes AI 50 choosing Anrok, its AI-native platform has become the go-to solution for fast-growing businesses handling global tax complexity so their teams can focus on growth. We’re proud to back Anrok on their mission to transform global compliance. 📖 Read more about Anrok’s Series C: https://lnkd.in/gs4jW5_W CC: Rajeev Dham, Demi Obayomi, Jasmine Yang

Congratulations to Harrison Chase, Ankush Gola, and the entire LangChain team on the $125M Series B! 🎉 To celebrate the news, Rajeev Dham and Anders Ranum sit down with Co-Founders Harrison and Ankush to talk about the company’s evolution from an open-source project to the platform for agent engineering trusted by Fortune 500s like LinkedIn, Workday, and Klarna—and why we’re proud to back them. 🎥 Watch the full conversation to hear about: • Real-world use cases, from AI Concierge Search at Etsy and Home Depot to Clay’s human-like Navigator tool • Balancing open source innovation with enterprise-grade reliability • What LangChain looks for in long-term partners and why they chose Sapphire 📖 Read more from Rajeev Dham, Anders Ranum, Alex Lehman, and Misty L. on why we’re excited to partner with LangChain: https://lnkd.in/g3xbKYRJ

ICYMI: Our Healthcare AI Market Map highlighting the innovators we believe are shaping the next generation of healthcare is now out. Few industries face higher stakes than healthcare, making AI’s emerging impact all the more critical. Provider shortages, skyrocketing admin costs, and fragmented data have created expensive, inefficient and frustrating experiences for patients and clinicians alike. Here are 3 major healthcare sectors where AI is creating meaningful change and that we’re most excited about: 1. Activating healthcare data at scale 📊 Healthcare generates enormous amounts of unstructured data that traditionally sat locked in silos. AI is now transforming this data into real-time insights, driving faster workflows, more coordinated care, and better patient outcomes. 2. Administrative Automation 📋 The administrative burden in healthcare has exploded—growing 20x faster than the physician workforce. AI can automate highly repetitive tasks like scheduling, billing, and documentation, reducing costs while giving clinicians more time with patients. 3. The 10x Provider 👩⚕️ With rising patient demand and a worsening clinician shortage, AI is augmenting providers and expanding system capacity. Agentic AI is stepping in to handle routine clerical and patient engagement functions, helping close the gap between supply and demand. At Sapphire, we see a growing wave of startups at the forefront of this transformation. Our Healthcare AI Market Map highlights the innovators that we believe are shaping what comes next. 🔗 Read the full blog by Cathy Gao, Aditya Reddy, Misty L. and Callum Kuo, and explore the map here: https://lnkd.in/gH7nZ2fW