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Short Answer:

For enterprise-grade, structured, TypeScript-heavy projects: Go with NestJS.

For maximum speed and modern tooling (greenfield): Use Fastify/Hono on Bun.

For battle-tested stability and ecosystem: Stick with Express.js on Node.js.

Bun is currently the fastest runtime and a great all-in-one tool, but Node.js still has the most mature ecosystem. Deno is the best choice if security-by-default and native web standards are your top priority.

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Answer selected by sattarrasouli
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