Multi-regional transcriptomic profiling reveals divergent molecular mechanisms in ALS-related neurodegeneration

Yu-Wen Hsu, Yu-Ning Lu, Mingming Liu, Jiou Wang

PLOS Genetics: published July 8, 2026 | https://doi.org/10.1371/journal.pgen.1012225

Highly frequent undesired insertional mutagenesis during Drosophila genome editing

Emma Källstig, Evelyne Ruchti, Medha Raman, Jamshid Asadzadeh, Bernard L. Schneider, Brian D. McCabe

PLOS Genetics: published July 9, 2026 | https://doi.org/10.1371/journal.pgen.1012192

Sex differences in the regulation and function of cellular immunity in Drosophila

Alexandra Dvoskin, Kevin Y. L. Ho, Michael Allara, Nicola Janz, Elizabeth Rideout, Juliet R. Girard, Guy Tanentzapf

PLOS Genetics: published July 10, 2026 | https://doi.org/10.1371/journal.pgen.1012151

Local ancestry inference with poorly-matched reference panels

Sharon R. Browning, Seth D. Temple, Brian L. Browning

PLOS Genetics: published July 13, 2026 | https://doi.org/10.1371/journal.pgen.1011919

Genome-wide cline analysis identifies new locus contributing to a barrier to gene flow across an Antirrhinum hybrid zone

David L. Field, Sean Stankowski, Taylor Reiter, Jitka Polechova, Desmond Bradley, Daniel M. Richardson, Annabel Whibley, Arka Pal, Daria Shipilina, Louis Boell, Melinda Pickup, Yongbiao Xue, Enrico Coen, Nicholas Barton

PLOS Genetics: published July 13, 2026 | https://doi.org/10.1371/journal.pgen.1012173

The B. subtilis translesion polymerase Pol Y1 is not strongly recruited to sites of replication upon different types of DNA damage

Sophia R. Martinez-Whitman, Chloe M. Santana, Alyssa P. Campbell, Denholm T. Feldman, Isaac E.Z. Jabaley, Luke G. O’Neal, McKayla E. Marrin, Elizabeth S. Thrall

PLOS Genetics: published July 14, 2026 | https://doi.org/10.1371/journal.pgen.1012246

High-resolution global recombination mapping in C. elegans reveals sexual dimorphisms shaped by meiotic chromosomal features and structures

Zachary D. Bush, John S. Conery, Hannah R. Wilson, Alice F. S. Naftaly, Devin Dinwiddie, Kenneth J. Hillers, Diana E. Libuda

PLOS Genetics: published July 14, 2026 | https://doi.org/10.1371/journal.pgen.1012237

An ancestral transmembrane transcription factor couples cell envelope regulation and the SOS response in Caulobacter crescentus

Kamilla Ankær Brejndal, Nikolaj Vestergaard Hansen, Koyel Ghosh, Sebastian Nielsen, Isabella Thorud, Lykke Haastrup Hansen, Lene Andrup Jakobsen, Martin Røssel Larsen, Clare Louise Kirkpatrick

PLOS Genetics: published July 15, 2026 | https://doi.org/10.1371/journal.pgen.1011986

A generalized test of genotype–phenotype causality in population-sampled nuclear families

Yushi Tang, John D. Storey

PLOS Genetics: published July 15, 2026 | https://doi.org/10.1371/journal.pgen.1012231

Apical spectrin organizes cortical actin filament bundles to pattern C. elegans cuticle ridges

Prioty Ferheen Sarwar, Trevor James Barker, Ken Nguyen, Fung-Yi Chan, David H. Hall, Ana Xavier Carvalho, Meera Vedavalli Sundaram

PLOS Genetics: published July 16, 2026 | https://doi.org/10.1371/journal.pgen.1012236

Wiz regulates clustered protocadherin genes by restricting CTCF/cohesin loop extrusion in a genomic-distance biased manner

Tianjie Li, Jingwei Li, Leyang Wang, Haiyan Huang, Qiang Wu

PLOS Genetics: published July 16, 2026 | https://doi.org/10.1371/journal.pgen.1012242

Contrasting evolutionary patterns of helper and sensor NRC NLRs in lettuce reflect functional divergence following subfunctionalization

Hsuan Pai, Toshiyuki Sakai, Andres Posbeyikian, Raoul Frijters, Yu Sugihara, Mauricio P. Contreras, Jiorgos Kourelis, Hiroaki Adachi, Sophien Kamoun, AmirAli Toghani

PLOS Genetics: published July 16, 2026 | https://doi.org/10.1371/journal.pgen.1012245

A genomic-led strategy to anticipate drug safety effects

Brian R. Ferolito, Andrea R. V. R. Horimoto, Kai Gravel-Pucillo, Daniel J. Golden, Hesam Dashti, Claudia Giambartolomei, Danielle Rasooly, Rachael Matty, Liam Gaziano, Yakov Tsepilov, Lauren Costa, Nicole Kosik, Harris Ioannidis, Mohd Karim, Giovanna Winicki, Fiona Hunter, Claudia Langenberg, John C. Whittaker, Million Veteran Program, Tianxi Cai, Gina M. Peloso, Barbara Zdrazil, Maya Ghoussaini, Andrew R. Leach, Sumitra Muralidhar, Ines A. Smit, Juan P. Casas, J. Michael Gaziano, Kelly Cho, Alexandre C. Pereira

PLOS Genetics: published July 16, 2026 | https://doi.org/10.1371/journal.pgen.1012211

A tumor-suppressive role of the PRC1 Polycomb epigenetic complex in the maintenance of adult Drosophila intestinal stem cell identity

Aurélia Joly, Ana-Maria Popmihaylova, Corinne Rancurel, Julie Soltys, Rihab Loudhaief, Armel Gallet, Edan Foley, Anne-Marie Martinez, Raphaël Rousset

PLOS Genetics: published July 17, 2026 | https://doi.org/10.1371/journal.pgen.1012226

Identifying severe COVID-19 risk variants modulating enhancer reporter activity in lung cells

Giovanna Weykopf, Wendy A. Bickmore, Simon C. Biddie, Elias T. Friman

PLOS Genetics: published July 17, 2026 | https://doi.org/10.1371/journal.pgen.1012222

Cross-family and phage-specific gene requirements for Klebsiella infection revealed by scalable RB-TnSeq genetic screens

Marissa R. Gittrich, Courtney M. Sanderson, Cara M. Noel, Erica Babusci, Sumeyra C. Selbes, Madeline Svab, Isabella Murray, Collis Bousliman, Ami Fofana, Aghiad Daboul, Jonathan Leopold, Alessandra Gon��alves de Melo, Marion Urvoy, Sylvain Moineau, Vivek K. Mutalik, Matthew B. Sullivan

PLOS Genetics: published July 20, 2026 | https://doi.org/10.1371/journal.pgen.1012233

Multi-ancestry colocalization approaches

Cathy Shen, Josée Dupuis, Qihuang Zhang

PLOS Genetics: published July 21, 2026 | https://doi.org/10.1371/journal.pgen.1012221

Photoperiodic patterns in miRNA-mRNA pairs and tRNA fragments revealed by time-course co-sequencing in Arabidopsis

Chun Chung Leung, Daniel A. Tarté, Joshua M. Gendron

PLOS Genetics: published July 22, 2026 | https://doi.org/10.1371/journal.pgen.1012229

Partitioning of the truncated insulin receptor DAF-2B between homodimers and heterodimers influences insulin signaling in C. elegans

Bryan A. Martinez, Anne M. Stene, Jonathan I. Hauser, Karla J. Opperman, Jonathan N. Sachs, Anthony R. Braun, Matthew S. Gill

PLOS Genetics: published July 23, 2026 | https://doi.org/10.1371/journal.pgen.1012240

Recurrent evolution of cryptic triploids in cultivated enset increases yield

Yann Dussert, James S. Borrell, Jonathan Stocks, Harriet V. Hunt, Oliver W. White, Paul Wilkin, Richard Buggs, Lucie Büchi, Sebsebe Demissew, Feleke Woldeyes, Ilia J. Leitch, Wendawek M. Abebe, Richard A. Nichols

PLOS Genetics: published July 24, 2026 | https://doi.org/10.1371/journal.pgen.1012241

Matrix Metalloprotease 1 (Mmp1) promotes cell fate change for epithelial-to-epithelial transition during regeneration after radiation damage in Drosophila

Michael Shiferaw, Lauren Orr, Korneel Hens, Tin Tin Su

PLOS Genetics: published July 30, 2026 | https://doi.org/10.1371/journal.pgen.1012257

Correction: Complexin in ivermectin resistance in body lice

The PLOS Genetics Editors

PLOS Genetics: published July 30, 2026 | https://doi.org/10.1371/journal.pgen.1012258

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Retraction: The PU.1-Modulated MicroRNA-22 Is a Regulator of Monocyte/Macrophage Differentiation and Acute Myeloid Leukemia

The PLOS Genetics Editors

PLOS Genetics: published July 9, 2026 | https://doi.org/10.1371/journal.pgen.1012224

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Age-based risk estimates for C9orf72^RE-related diseases: Theoretical developments and added value for genetic counseling

Dominique de Vienne, Damien M. de Vienne

PLOS Genetics: published July 13, 2026 | https://doi.org/10.1371/journal.pgen.1012230