It is well known that in LaTeX $ABCD$ is different from $\mathit{ABCD}$ as the former represents the multiplication of four variables while the latter represents some single object such as a rectangle.
In solid geometry, suppose there is a cuboid ABCD-A1B1C1D1. Which one of the following is preferred/recommended? From the output it seems that \mathit is unnecessary for A1B1C1D1.
\documentclass{article}
\begin{document}
\begin{itemize}
\item $\mathit{ABCD}$-$\mathit{A_1B_1C_1D_1}$
\item $\mathit{ABCD}$-$\mathit{A_{\mathnormal{1}}B_{\mathnormal{1}}C_{\mathnormal{1}}D_{\mathnormal{1}}}$
\item $\mathit{ABCD}$-$A_1B_1C_1D_1$
\end{itemize}
\end{document}



\mathit{A}_{1}is right;\mathit{A_{\mathnormal{1}}}is definitely wrong.$\mathit{ABCD}$-$\mathit{A}_1\mathit{B}_1\mathit{C}_1\mathit{D}_1$. Well, quote tedious :-(\newcommand\cuboid[5][1]{\mathit{#2}_{#1}\mathit{#3}_{#1}\mathit{#4}_{#1}\mathit{#5}_{#1}}so\cuboid{A}{B}{C}{D} \cuboid[3]{E}{F}{G}{H}or something?